Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial

Autor: Petra Bago, Monika Tomić, Rosana Troskot, Karolina Majstorović, Nastja Kučišec, Vinko Bakula, Željka Belošić-Halle, Josip Bago
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Microbiology (medical)
Adult
Male
medicine.medical_specialty
Time Factors
medicine.drug_class
Antibiotics
Moxifloxacin
lcsh:QR1-502
Drug resistance
Gastroenterology
Drug Administration Schedule
lcsh:Microbiology
law.invention
Helicobacter Infections
lcsh:Infectious and parasitic diseases
Antibiotic resistance
Randomized controlled trial
Anti-Infective Agents
law
Internal medicine
Drug Resistance
Bacterial
medicine
Humans
lcsh:RC109-216
Antiinfective agent
Aza Compounds
Helicobacter pylori
antimicrobial resistance
moxifloxacin therapy
biology
business.industry
Research
lcsh:RM1-950
General Medicine
Amoxicillin
Middle Aged
biology.organism_classification
bacterial infections and mycoses
Surgery
Infectious Diseases
Treatment Outcome
lcsh:Therapeutics. Pharmacology
Quinolines
Female
business
medicine.drug
Fluoroquinolones
Zdroj: Annals of Clinical Microbiology and Antimicrobials, Vol 9, Iss 1, p 13 (2010)
Annals of Clinical Microbiology and Antimicrobials
ISSN: 1476-0711
Popis: Introduction Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments. Aims&methods Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compared with 10 days moxifloxacin with lansoprasole and amoxycillin according to moxifloxacin resistance. Patients with non-ulcer dyspepsia who had culture and histology positive Hp infection (n = 150) were randomly assigned into two groups. The first group (n = 75) received moxifloxacin 400 mg/d during 7 days and the other (n = 75) received moxifloxacin 400 mg/d during 10 days. All patients received amoxycillin 1 g twice daily, lansoprasole 30 mg twice daily. All Hp cultures were tested for sensitivity to moxifloxacin. Results 138 patients (92%) completed the study, 68 in the first group and 70 in the second. Eradication rates were 84% (57/68) and 76% (57/75) in the 7 days moxifloxacin group and 90% and 84% in the second group (63/70, 63/75) according to the PP and ITT analysis; p = n.s. Among 129 patients (86% of study group), 6% of strains were primary resistant to moxifloxacin. Eradication of moxifloxacin sensitive/resistant strains was 98%/66%, p < 0.05 Conclusion According to our results we recommend 7 days moxiflixacin based triple therapy.
Databáze: OpenAIRE
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