1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients
| Autor: | A. Del-Toro-Arreola, Adrian Daneri-Navarro, Antonio Oceguera-Villanueva, Juan Manuel Castro-Cervantes, Ramón Franco-Topete, Luz María Adriana Balderas-Peña, A. Duran-Cardenas, L.M. Jimenez-Perez, Antonio Quintero-Ramos, Gilberto Morgan-Villela, Susan Andrea Gutierrez-Rubio |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Genotype medicine.drug_class Breast Neoplasms Polymerase Chain Reaction Polymorphism Single Nucleotide law.invention Breast cancer law Risk Factors Internal medicine Genetics medicine Ethnicity Humans Genetic Predisposition to Disease Allele Molecular Biology Mexico Polymerase chain reaction Alleles Aged Regulation of gene expression Aged 80 and over business.industry Case-control study General Medicine Middle Aged medicine.disease Genotype frequency Gene Expression Regulation Neoplastic Postmenopause Premenopause Estrogen Case-Control Studies Female business Polymorphism Restriction Fragment Length |
| Zdroj: | Genetics and molecular research : GMR. 14(1) |
| ISSN: | 1676-5680 |
| Popis: | MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification. Molecular subtypes as well as allele and genotype frequencies were analyzed. A total of 248 women with initial breast cancer diagnosis and 180 ethnically matched, healthy, unrelated individuals were enrolled. Polymerase chain reaction-restriction fragment length polymorphism was performed to detect polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene. Premenopausal T allele carriers of the 3435 C/T polymorphism showed a 2-fold increased risk of breast cancer with respect to the reference and postmenopausal groups, as well as triple-negative expression regarding the luminal A/B molecular subrogated subtypes. In contrast, the CT genotype of the 1236 polymorphism was a protective factor against breast cancer. We conclude that the T allele carrier of the 3435 C/T polymorphism in the ABCB1 gene in combination with an estrogen receptor-negative status may be an important risk factor for breast cancer development in premenopausal women. |
| Databáze: | OpenAIRE |
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