Molecular Subtypes of Prostate Cancer
| Autor: | Kaveri Arora, Christopher E. Barbieri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male IDH1 Disease urologic and male genital diseases Bioinformatics TMPRSS2 Metastasis Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Biomarkers Tumor Medicine Humans Neoplasm Metastasis business.industry Prostatic Neoplasms Androgen Antagonists medicine.disease Androgen receptor Prostatic Neoplasms Castration-Resistant 030104 developmental biology Oncology Receptors Androgen 030220 oncology & carcinogenesis Localized disease Mutation Disease Progression business |
| Zdroj: | Current oncology reports. 20(8) |
| ISSN: | 1534-6269 |
| Popis: | This review will examine the taxonomy of PCa subclasses across disease states, explore the relationship among specific alterations, and highlight current clinical relevance. Prostate cancer (PCa) is driven by multiple genomic alterations, with distinct patterns and clinical implications. Alterations occurring early in the timeline of the disease define core subtypes of localized, treatment-naive PCa. With time, an increase in number and severity of genomic alterations adds molecular complexity and is associated with progression to metastasis. These later events are not random and are influenced by the underlying subclasses. All the subclasses of localized disease initially respond to androgen deprivation therapy (ADT), but with progression to castrate-resistant PCa (CRPC), mechanisms of resistance against ADT shift the molecular landscape. In CRPC, resistance mechanisms largely define the biology and sub-classification of these cancers, while clinical relevance and opportunities for precision therapy are still being defined. |
| Databáze: | OpenAIRE |
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