HERPES SIMPLEX VIRUS ENCEPHALITIS: PROBLEMS IN DIAGNOSIS
| Autor: | J. Munro, Sheila J. Wallace, P. D. Cameron |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pediatrics Adolescent medicine.disease_cause Herpesviridae Serology Epilepsy Developmental Neuroscience Pregnancy Alphaherpesvirinae Convulsion medicine Humans Child Retrospective Studies medicine.diagnostic_test biology business.industry Brain biopsy Herpes Simplex biology.organism_classification medicine.disease Child Preschool Pediatrics Perinatology and Child Health Encephalitis Female Neurology (clinical) Viral disease medicine.symptom business |
| Zdroj: | Developmental Medicine & Child Neurology. 34:134-140 |
| ISSN: | 1469-8749 0012-1622 |
| DOI: | 10.1111/j.1469-8749.1992.tb14979.x |
| Popis: | Six children aged 13 days to nine years with herpes simplex encephalitis (HSE) are presented. Institution of appropriate antiviral treatment was later than six days in three cases; original diagnosis in these cases were post-traumatic epilepsy, bacterial meningitis and febrile convulsion. Initially pyrexia was absent in two cases and cranial CT was normal in two cases. Encephalitic changes were observed on the EEGs of five children. Diagnosis was confirmed by paired serological titres, brain biopsy, vesicle culture and CSF titres. The outcome for all six children was poor. HSE should always be considered in children presenting with focal seizures, even when apyrexial and with normal CT findings. In such situations, saving CSF for antibody titres or antigen identification should be routine practice. Treatment with acyclovir is justified before precise virological diagnosis has been established. |
| Databáze: | OpenAIRE |
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