Temporal Trends in Pharmacological Stroke Prevention in Patients with Acute Ischemic Stroke and Known Atrial Fibrillation

Autor:	Maria Konieczny, Karl Georg Haeusler, Ulrike Grittner, Juliane Herm, Rudi Ruschmann, Matthias Endres, Simon Hellwig
Rok vydání:	2020
Předmět:	Male trends [Secondary Prevention] Time Factors prevention & control [Brain Ischemia] Administration Oral Brain Ischemia 0302 clinical medicine Risk Factors administration & dosage [Fibrinolytic Agents] Germany diagnosis [Brain Ischemia] Atrial Fibrillation Antithrombotic Secondary Prevention drug therapy [Atrial Fibrillation] Practice Patterns Physicians' adverse effects [Anticoagulants] Stroke Acute ischemic stroke Stroke etiology Aged 80 and over Ischemic stroke Rehabilitation Atrial fibrillation adverse effects [Fibrinolytic Agents] diagnosis [Stroke] trends [Practice Patterns Physicians'] Treatment Outcome administration & dosage [Anticoagulants] Stroke prevention Cardiology Female adverse effects [Platelet Aggregation Inhibitors] Cardiology and Cardiovascular Medicine epidemiology [Stroke] prevention & control [Stroke] epidemiology [Atrial Fibrillation] medicine.medical_specialty epidemiology [Germany] Non-vitamin K-dependent oral anticoagulants 03 medical and health sciences Fibrinolytic Agents Internal medicine medicine Hospital discharge epidemiology [Brain Ischemia] Humans In patient ddc:610 Medical prescription Secondary stroke prevention Aged Retrospective Studies business.industry diagnosis [Atrial Fibrillation] administration & dosage [Platelet Aggregation Inhibitors] Anticoagulants medicine.disease Drug Utilization Surgery Neurology (clinical) trends [Drug Utilization] business Platelet Aggregation Inhibitors 030217 neurology & neurosurgery
Zdroj:	Journal of stroke and cerebrovascular diseases 29(12), 105266-(2020). doi:10.1016/j.jstrokecerebrovasdis.2020.105266
ISSN:	1052-3057
DOI:	10.1016/j.jstrokecerebrovasdis.2020.105266
Popis:	Oral anticoagulation (OAC) substantially reduces stroke risk in patients with atrial fibrillation (AF) at risk for stroke. Whether non-vitamin K-dependent oral anticoagulants (NOACs) improve OAC use in stroke prevention requires investigation.To investigate temporal trends of OAC use in patients with known AF pre-stroke, we retrospectively analyzed records of 6,803 stroke patients admitted in 2003-2004 (n=1,496), 2008-2010 (n=1,638) or 2013-2015 (n=3,669) to the Charité-Universitätsmedizin Berlin, Germany. Adjusted regression models were used to identify factors associated with OAC use.Of 1,209 AF patients (mean age 79 years, 55.9% female) with given indication for OAC according to the CHADS2/CHA2DS2-VASc score, 484 (40.0%) were anticoagulated prior to the index stroke, 458 (37.9%) received antiplatelets and 236 (19.5%) had no antithrombotic medication. Compared to 2003-2004 and 2008-2010, there was a higher rate of pre-admission OAC in 2013-2015 (28.2% vs. 49.6%, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0810bbbec0fd4d173a2054a43e02e50d https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105266 Zobrazit plný text záznamu Full Text from ScienceDirect