A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders
| Autor: | José M. Bautista, Seyedeh Masoomeh Noorbakhsh, Gholamreza Azizi, Ali N. Kamali, Haleh Hamedifar, Farhad Jadidi-Niaragh, Reza Yazdani |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Immunology chemical and pharmacologic phenomena Inflammatory bowel disease Autoimmune Diseases Pathogenesis Interferon-gamma 03 medical and health sciences 0302 clinical medicine RAR-related orphan receptor gamma Interferon Animals Humans Medicine Molecular Biology Inflammation Orphan receptor business.industry Multiple sclerosis Interleukin-17 Interleukin hemic and immune systems Th1 Cells medicine.disease 030104 developmental biology Primary immunodeficiency Th17 Cells T-Box Domain Proteins business 030215 immunology medicine.drug |
| Zdroj: | Molecular Immunology. 105:107-115 |
| ISSN: | 0161-5890 |
| Popis: | The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells co-express retinoic acid-related orphan receptor gamma t (RORγt) and transcription factor T-box-expressed-in-T-cells (T-bet) and produce both interleukin (IL)-17 and interferon (IFN)-γ. Recent reports have shown that Th1-like Th17 cells play crucial roles in the pathogenesis of autoimmune diseases such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, as well as, some primary immunodeficiency with autoimmune features. Here, the actual mechanisms for Th17 cells plasticity to Th1-like Th17 cells are discussed and reviewed in association to the role that Th1-like Th17 cells have on inflammatory and autoimmune disorders. |
| Databáze: | OpenAIRE |
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