A single-cell genome perspective on studying intracellular associations in unicellular eukaryotes
| Autor: | Shailesh V. Date, Tomáš Tyml, Tanja Woyke |
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| Rok vydání: | 2019 |
| Předmět: |
Ecology (disciplines)
1.1 Normal biological development and functioning Cell Genomics Computational biology Biology unicellular eukaryotes Genome 2.2 Factors relating to physical environment Medical and Health Sciences General Biochemistry Genetics and Molecular Biology Extant taxon Cellular dna Underpinning research medicine Genetics 2.2 Factors relating to the physical environment Giant Virus Aetiology cultivation bias giant viruses Evolutionary Biology intracellular associations single-cell genomics Human Genome Articles Biological Sciences Opinion Piece medicine.anatomical_structure Eukaryotic Cells Generic health relevance Single-Cell Analysis General Agricultural and Biological Sciences endosymbiont Intracellular |
| Zdroj: | Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 374, iss 1786 Philosophical Transactions of the Royal Society B: Biological Sciences |
| Popis: | Single-cell genomics (SCG) methods provide a unique opportunity to analyse whole genome information at the resolution of an individual cell. While SCG has been extensively used to investigate bacterial and archaeal genomes, the technique has been rarely used to access the genetic makeup of uncultivated microbial eukaryotes. In this regard, the use of SCG can provide a wealth of information; not only do the methods allow exploration of the genome, they can also help elucidate the relationship between the cell and intracellular entities extant in nearly all eukaryotes. SCG enables the study of total eukaryotic cellular DNA, which in turn allows us to better understand the evolutionary history and diversity of life, and the physiological interactions that define complex organisms. This article is part of a discussion meeting issue ‘Single cell ecology’. |
| Databáze: | OpenAIRE |
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