Differential expression of TLR2 and TLR4 in α4β7-positive leukocytes of patients with axial spondyloarthritis
| Autor: | José Pablo Romero-López, Ethel García-Latorre, María Lilia Domínguez-López, Jiménez-Zamudio L, Ruben Burgos-Vargas, Julio Casasola-Vargas, David Gómez-Martínez |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Integrins T-Lymphocytes Monocytes Flow cytometry 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology T-Lymphocyte Subsets medicine Humans Pharmacology (medical) Receptor 030203 arthritis & rheumatology Toll-like receptor Leukocyte L1 Antigen Complex medicine.diagnostic_test business.industry Receptors Antigen T-Cell gamma-delta Faecal calprotectin Toll-Like Receptor 2 Toll-Like Receptor 4 TLR2 030104 developmental biology Case-Control Studies Immunology TLR4 Spondylarthropathies Female business |
| Zdroj: | Rheumatology (Oxford, England). 59(4) |
| ISSN: | 1462-0332 |
| Popis: | Objectives Expression of α4β7 integrin can identify gut-homing immune cells. This study aimed to determine the expression of Toll-like receptor 2 (TLR2) and TLR4 in α4β7-positive leukocytes of patients with axial SpA (axSpA). Methods We analysed the frequencies of α4β7-positive T cells, Tγδ cells and monocytes in 14 patients with axSpA and 14 healthy controls, together with the expression of TLR2 and TLR4 by flow cytometry. Also, the concentration of faecal calprotectin was measured in all patients and controls. Results We found significantly higher percentages of α4β7-positive T (P = 0.026) and Tγδ cells (P = 0.0118) in the patients with axSpA than in controls; these cells showed differential expression of TLR2 and TLR4 when compared with α4β7-negative cells. Such differences were not correlated with disease activity or faecal calprotectin concentration. Conclusion There is an increase in circulating α4β7-positive T and Tγδ cells in patients with axSpA. These cells differentially express TLR2 and TLR4. |
| Databáze: | OpenAIRE |
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