A model of immunologic lung injury induced by trimellitic anhydride inhalation: Antibody response*
| Autor: | Hatoum Ns, Chandler Mj, C.R. Zeiss, Paul J. Garvin, Leach Cl, Jean-Claude Roger, Levitz D, Ratajczak Hv |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Lung Diseases
Male Pathology medicine.medical_specialty Immunology Phthalic Acids Serum albumin Hemorrhage Lung injury Antibodies Trimellitic anhydride chemistry.chemical_compound Administration Inhalation Respiratory Hypersensitivity medicine Animals Immunology and Allergy Respiratory system Lung Inhalation biology business.industry Respiratory disease Rats Inbred Strains Organ Size medicine.disease Rats Disease Models Animal medicine.anatomical_structure chemistry Phthalic Anhydrides Antibody Formation Toxicity biology.protein Female business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 79:59-63 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/s0091-6749(87)80017-9 |
| Popis: | We studied lung injury induced in Sprague-Dawley rats by trimellitic anhydride (TMA) inhalation. Groups of 40 male and 20 female rats were exposed to TMA by inhalation at target concentrations of 0, 10, 30, 100, and 300 micrograms/m3, 6 hours per day, 5 days per week, for 2 weeks. Rats in each exposure group were sacrificed after 10 exposures or rested for 12 days and either sacrificed or received a 6-hour TMA challenge at their initial exposure levels and sacrificed at 24 hours. At each sacrifice, serum antibody to radiolabeled trimellityl rat serum albumin (RSA-TM) was measured by an ammonium sulfate technique, and lung pathology was determined. After 10 days of exposure, external hemorrhagic lung foci were directly related to the exposure concentration of TMA. Serum antibody binding of RSA-TM correlated with exposure concentration, hemorrhagic lung foci, and lung weight. There was healing of lung lesions 12 days after exposure with a return of lung lesions only 18 hours after the 6-hour inhalation challenge. A correlation between serum antibody to RSA-TM, hemorrhagic foci, and lung weight existed after challenge. This model clarifies two clinical entities observed in exposed workers, the late respiratory systemic and the pulmonary disease-anemia syndromes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|