Tissue velocity imaging of the left atrium predicts response to flecainide in patients with acute atrial fibrillation
| Autor: | Tammo Delhaas, Isabelle C. Van Gelder, Ione Limantoro, Ulrich Schotten, Ron Pisters, Harry J.G.M. Crijns, Cees B. de Vos, Ernaldo G. Marcos, Bob Weijs, Yuri Blaauw, Robert G. Tieleman |
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| Přispěvatelé: | MUMC+: DA BV AIOS Radiologie (9), Biomedische Technologie, MUMC+: MA Med Staf Artsass Cardiologie (9), Cardiologie, Fysiologie, MUMC+: MA Cardiologie (9), RS: CARIM - R2 - Cardiac function and failure, RS: MHeNs - R3 - Neuroscience, Cardiovascular Centre (CVC) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty ACUTE CONVERSION medicine.medical_treatment PROPAFENONE 1ST DAYS Propafenone Cardioversion Electrocardiography Interquartile range Predictive Value of Tests Physiology (medical) Internal medicine medicine Humans Sinus rhythm Heart Atria Tissue Velocity Imaging Infusions Intravenous CLINICAL-EFFICACY Flecainide ANTIARRHYTHMIC-DRUGS Pharmacological cardioversion Ejection fraction business.industry P wave Atrial fibrillation Middle Aged medicine.disease RECENT-ONSET CARDIOVERSION Treatment Outcome CONDUCTION Echocardiography Anesthesia Cardiology Female SINUS RHYTHM Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug CYCLE LENGTH |
| Zdroj: | Heart Rhythm, 11(3), 478-484. Elsevier Science Heart Rhythm, 11(3), 478-484. ELSEVIER SCIENCE INC |
| ISSN: | 1556-3871 1547-5271 |
| Popis: | BACKGROUND Acute atrial fibrillation (AF) is often treated with the administration of intravenous flecainide; however, this treatment may not always be successful and is potentially hazardous. Previous studies suggest that electro-echocardiographic tissue velocity imaging (TVI) of the atrial wall may reflect atrial remodeling.OBJECTIVE To study whether atrial TVI can be used to identify nonresponders of flecainide administered intravenously in patients with acute AF.METHODS We used atrial TVI to measure atrial fibrillatory cycle Length determined by using tissue velocity imaging (AFCL-TVI) and atrial fibrillatory wall motion velocity determined by using tissue velocity imaging (AFV-TVI) in the left atrium in 52 (55%) patients presenting with acute AF in the emergency department. These 2 parameters reflect electrical and structural remodeling, respectively. Standard baseline characteristics were recorded.RESULTS Patients were predominantly men (76%) and 64 7 11 years old. Thirty-six (69%) patients had successful cardioversion after flecainide infusion. There were no significant differences in baseline characteristics between responders and nonresponders. Patients with a successful cardioversion had a longer mean AFCL-TVI and higher median (interquartile range) AFV-TVI compared with patients with failed cardioversion: 172 L- 29 ms vs 137 L- 35 ms (PCONCLUSIONS Electro-echocardiographic atrial TVI measurement is a promising noninvasive tool for predicting outcome of pharmacological cardioversion. A short AFCL-TVI and a low AFV-TVI are related to failure of cardioversion of AF using flecainide. tj (C) 2014 Heart Rhythm Society. All rights reserved. |
| Databáze: | OpenAIRE |
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