A Scheme for Detecting Every Single Target Molecule with Surface-Enhanced Raman Spectroscopy
| Autor: | Johan Grand, Idrissa Sow, Walter R. C. Somerville, Nordin Félidj, Jean Aubard, Eric C. Le Ru, Gaëlle Charron, Georges Lévi, Pablo G. Etchegoin, Mona Tréguer-Delapierre |
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| Přispěvatelé: | The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Interfaces, Traitements, Organisation et Dynamique des Systèmes (ITODYS (UMR_7086)), Université Paris Diderot - Paris 7 (UPD7)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université de Bordeaux (UB), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB) |
| Rok vydání: | 2011 |
| Předmět: |
Analyte
Metallic nanostructures Analytical chemistry Bioengineering 02 engineering and technology Complex Mixtures 010402 general chemistry 01 natural sciences symbols.namesake Adsorption Materials Testing Single molecule detection Bianalyte SERS Molecule General Materials Science Plasmon CTAB bilayer Chemistry Mechanical Engineering Surface-enhanced Raman spectroscopy Site-selective adsorption [CHIM.MATE]Chemical Sciences/Material chemistry General Chemistry Surface Plasmon Resonance 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Chemical physics Selective adsorption symbols Plasmonics 0210 nano-technology Raman spectroscopy Algorithms |
| Zdroj: | Nano Letters Nano Letters, American Chemical Society, 2011, 11 (11), pp.5013-5019. ⟨10.1021/nl2030344⟩ |
| ISSN: | 1530-6992 1530-6984 |
| Popis: | International audience; Surface-enhanced Raman spectroscopy (SERS) is now a well-established technique for the detection, under appropriate conditions, of single molecules (SM) adsorbed on metallic nanostructures. However, because of the large variations of the SERS enhancement factor on the surface, only molecules located at the positions of highest enhancement, so-called hot-spots, can be detected at the single-molecule level. As a result, in all SM-SERS studies so far only a small fraction, typically less than 1%, of molecules are actually observed. This complicates the analysis of such experiments and means that trace detection via SERS can in principle still be vastly improved. Here we propose a simple scheme, based on selective adsorption of the target analyte at the SERS hot-spots only, that allows in principle detection of every single target molecule in solution. We moreover provide a general experimental methodology, based on the comparison between average and maximum (single molecule) SERS enhancement factors, to verify the efficiency of our approach. The concepts and tools introduced in this work can readily be applied to other SERS systems aiming for detection of every single target molecule. |
| Databáze: | OpenAIRE |
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