Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder
| Autor: | Minh Duy Ngo, Michael Heke, Phuong Anh Thi Nguyen, Binh Duc Duong, Kien Trung Tran, Doan Van Ngo, Nicholas R. Forsyth, Hoang-Phuong Nguyen, Tung Thi Thanh Dang, Liem Nguyen Thanh, Viet Anh Bui, Hoa Thi Phuong Bui, Phuong T. M. Dam |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty autism spectrum disorder Human Clinical Articles stem cell transplantation 03 medical and health sciences 0302 clinical medicine Human Clinical Article Bone Marrow medicine Humans Child Adverse effect Bone Marrow Transplantation business.industry Cell Biology General Medicine medicine.disease Corrigenda R1 Vineland Adaptive Behavior Scale Clinical trial Transplantation 030104 developmental biology medicine.anatomical_structure Vietnam Autism spectrum disorder educational intervention Leukocytes Mononuclear Childhood Autism Rating Scale Autism bone marrow mononuclear cell Bone marrow business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem Cells Translational Medicine Stem Cells Transl Med |
| ISSN: | 2157-6580 2157-6564 |
| DOI: | 10.1002/sctm.20-0102 |
| Popis: | The aim of this study was to evaluate the safety and efficacy of autologous bone marrow mononuclear cell transplantation combined with educational intervention for children with autism spectrum disorder. An open‐label clinical trial was performed from July 2017 to August 2019 at Vinmec International Hospital, Hanoi, Vietnam. Thirty children who fulfilled the autism criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and had Childhood Autism Rating Scale (CARS) scores >37 were selected. Bone marrow was harvested by anterior iliac crest puncture under general anesthesia. The volume collected was as follows: 8 mL/kg for patients under 10 kg (80 mL + [body weight in kg − 10] × 7 mL) for patients above 10 kg. Mononuclear cells were isolated with a Ficoll gradient and then infused intrathecally. The same procedure was repeated 6 months later. After the first transplantation, all patients underwent 8 weeks of educational intervention based on the Early Start Denver Model. There were no severe adverse events associated with transplantation. The severity of autism spectrum disorder (ASD) was significantly reduced, with the median CARS score decreasing from 50 (range 40‐55.5) to 46.5 (range 33.5‐53.5) (P |
| Databáze: | OpenAIRE |
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