Virus-like particles in vaccine development
| Autor: | Maria Candida M. Mellado, Manuel J.T. Carrondo, António Roldão, Paula M. Alves, Leda R. Castilho |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
viruses
Immunology Context (language use) medicine.disease_cause complex mixtures Virus Cell Line Drug Discovery medicine Animals Humans Nanotechnology Vaccines Virus-Like Particle Pharmacology Hepatitis B virus Clinical Trials as Topic biology Parvovirus Viral Vaccine Gardasil Virus Assembly Vaccination virus diseases Viral Vaccines biology.organism_classification Virology Virus Diseases Molecular Medicine Cervarix medicine.drug Biotechnology |
| Zdroj: | Expert review of vaccines. 9(10) |
| ISSN: | 1744-8395 |
| Popis: | Virus-like particles (VLPs) are multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome, potentially yielding safer and cheaper vaccine candidates. A handful of prophylactic VLP-based vaccines is currently commercialized worldwide: GlaxoSmithKline's Engerix (hepatitis B virus) and Cervarix (human papillomavirus), and Merck and Co., Inc.'s Recombivax HB (hepatitis B virus) and Gardasil (human papillomavirus) are some examples. Other VLP-based vaccine candidates are in clinical trials or undergoing preclinical evaluation, such as, influenza virus, parvovirus, Norwalk and various chimeric VLPs. Many others are still restricted to small-scale fundamental research, despite their success in preclinical tests. This article focuses on the essential role of VLP technology in new-generation vaccines against prevalent and emergent diseases. The implications of large-scale VLP production are discussed in the context of process control, monitorization and optimization. The main up- and down-stream technical challenges are identified and discussed accordingly. Successful VLP-based vaccine blockbusters are briefly presented concomitantly with the latest results from clinical trials and the recent developments in chimeric VLP-based technology for either therapeutic or prophylactic vaccination. |
| Databáze: | OpenAIRE |
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