Association of Mouse Mammary Tumor Virus Superantigen with MHC Class II During Biosynthesis
| Autor: | Brigitte T. Huber, Paula Wolf Bryant, Ping-Ning Hsu, Hidde L. Ploegh, Natalie Sutkowski, Brian McLellan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
CD74
Amino Acid Motifs Immunology chemical and pharmacologic phenomena Biology Mice Dogs Antigen Mammary tumor virus Superantigen Animals Humans Immunology and Allergy Antigens Viral Antigen Presentation HLA-D Antigens Mammary tumor MHC class II Membrane Glycoproteins Superantigens Cell-Free System Endoplasmic reticulum Mouse mammary tumor virus HLA-DR1 Antigen Histocompatibility Antigens Class II Models Immunological hemic and immune systems biology.organism_classification Virology Cell biology Antigens Differentiation B-Lymphocyte Mammary Tumor Virus Mouse Protein Biosynthesis Mutation biology.protein Rabbits Dimerization Oligopeptides Protein Binding |
| Zdroj: | The Journal of Immunology. 166:3309-3314 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.166.5.3309 |
| Popis: | Mouse mammary tumor viruses encode superantigens that interact with MHC class II proteins and stimulate T cells. We show here that presentation of mouse mammary tumor virus superantigen does not require DM. Furthermore, we have identified a strong class II peptide binding motif in the Mtv-7 superantigen, and we show that this motif is necessary for association with class II molecules in in vitro translation and in vivo functional assays. Our results suggest that endogenously synthesized viral superantigen can bind to MHC class II heterodimers during biosynthesis in the endoplasmic reticulum in a manner analogous to that used by the class II-associated invariant chain. |
| Databáze: | OpenAIRE |
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