Head injuries in four British neurosurgical centres

Autor:	G. D. Murray, M. D. M. Shaw, L. S. Murray, Graham M. Teasdale, John D. Pickard, D. J. Miller
Rok vydání:	1999
Předmět:	Adult Male Pediatrics medicine.medical_specialty Traumatic brain injury Poison control Case mix index Intensive care Injury prevention medicine Craniocerebral Trauma Humans Prospective Studies Practice Patterns Physicians' Clinical Trials as Topic business.industry Data Collection Head injury Accidents Traffic General Medicine Odds ratio Length of Stay Middle Aged medicine.disease Organizational Policy United Kingdom Emergency medicine Intracranial pressure monitoring Female Surgery Neurology (clinical) business
Zdroj:	British Journal of Neurosurgery. 13:564-569
ISSN:	1360-046X 0268-8697
Popis:	An issue in the design of trials in traumatic brain injury is whether variation amongst centres in 'conventional' management could mask the impact of a powerful new pharmacological agent. We report the results of an observational study of 988 patients admitted to one of four British neurosurgical units between 1986 and 1988 within 3 days of a severe head injury. The centres fell into two pairs on the basis of the 'intensity' of management. In Edinburgh and Southampton, more frequent use of intracranial pressure monitoring, ventilation and osmotic diuretics was made than in Glasgow and Liverpool. The odds ratio for an independent outcome at 6 months in Edinburgh or Southampton, relative to Glasgow or Liverpool, controlling for case mix, was 1.43 (95% CI, 1.03-1.98, p = 0.033). Thus, there is weak evidence of an association between the approach to management and clinical outcome at 6 months.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0802dc5567830b068f2a582ece437fc9 https://doi.org/10.1080/02688699943060 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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