Bone morphogenetic protein-4 and bone morphogenetic protein receptors expressions in the adult rat eye
| Autor: | Kohji Sato, Yuka Maruyama-Koide, Sumiko Mikawa, Takeshi Sasaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Histology Biophysics BMP4 Bone Morphogenetic Protein 4 Biology Eye Retina 03 medical and health sciences Ciliary body Internal medicine medicine Animals Bone morphogenetic protein receptor Rats Wistar lcsh:QH301-705.5 Corneal epithelium Original Paper Gene Expression Profiling eye Cell Biology Bone Morphogenetic Protein Receptors Immunohistochemistry Cell biology BMPR2 Rats BMPRII Bone morphogenetic protein 7 030104 developmental biology medicine.anatomical_structure Bone morphogenetic protein 5 Endocrinology Bone morphogenetic protein 4 Gene Expression Regulation lcsh:Biology (General) Lens (anatomy) BMPRIB BMPRIA |
| Zdroj: | European Journal of Histochemistry, Vol 61, Iss 3 (2017) European Journal of Histochemistry : EJH |
| ISSN: | 2038-8306 |
| Popis: | We investigated the expressions of bone morphogenetic protein-4 (BMP4) and its receptors, bone morphogenetic protein receptor IA (BMPRIA), bone morphogenetic protein receptor IB (BMPRIB) and bone morphogenetic protein receptor II (BMPRII) in the adult rat eye. Interesting differences in expression profile were observed between BMPRIA and BMPRIB in the retina. BMPRIA-like immunoreactivity (IR) was very intensely seen in the photoreceptor layer, while BMPRIB-IR was mainly observed in the other layers. In the cornea, BMP4, BMPRIA, BMPRIB and BMPRII-IRs were abundantly seen in the cell body of basal cells in the corneal epithelium, and endothelium. In the lens, BMP4, BMPRIA, BMPRIB and BMPRII-IRs were observed in epithelial cells, lens cortical fiber cells, however they were not seen in the capsule and the central region of the lens. In the iris and ciliary body, strong BMP4 and BMPRIB-IRs were observed in nonpigmented epithelium. These results suggest that different kinds of BMP signaling should be needed in different areas in the adult eye to keep the shapes, differentiation levels, and functions of various cells. |
| Databáze: | OpenAIRE |
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