Antitrypanosomal Activities of Tryptanthrins
| Autor: | John Scovill, Elizabeth Blank, Elizabeth Nenortas, Theresa A. Shapiro, Michael Konnick |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Antifungal
medicine.drug_class Trypanosoma brucei brucei Pharmacology Trypanosoma brucei Structure-Activity Relationship parasitic diseases medicine Animals Humans Structure–activity relationship Pharmacology (medical) Cells Cultured Trypanocidal agent biology Kinetoplastida Biological activity biology.organism_classification Trypanocidal Agents In vitro Infectious Diseases Biochemistry Susceptibility Quinazolines Molecular targets |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 46:882-883 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.46.3.882-883.2002 |
| Popis: | New drugs and molecular targets are needed against Trypanosoma brucei , the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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