A paradoxical castration effect on LH-RH levels in male rat hypothalamus and serum
| Autor: | Chris Howitt, Seon H. Shin, John V. Milligan |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Hypophysectomy medicine.medical_treatment Hypothalamus Radioimmunoassay Hypothalamic–pituitary–gonadal axis General Biochemistry Genetics and Molecular Biology Gonadotropin-Releasing Hormone chemistry.chemical_compound Internal medicine Male rats medicine Animals Testosterone General Pharmacology Toxicology and Pharmaceutics business.industry Rats Inbred Strains General Medicine Luteinizing Hormone Rats Endocrinology Castration chemistry Luteinizing hormone business Orchiectomy Hormone |
| Zdroj: | Life sciences. 14(12) |
| ISSN: | 0024-3205 |
| Popis: | Serum and hypothalamic luteinizing hormone releasing hormone (LH-RH) was lowered in young mature male rats after castration. Testosterone injections raised the hypothalamic LH-RH content significantly. The mean value of serum LH level was elevated by testosterone, but not significantly. Hypothalamic LH-RH content was also lowered by hypophysectomy. In this circumstance, testosterone injections significantly increased LH-RH content. These results suggest that there may be a positive feedback of testosterone upon the hypothalamic LH-RH release and synthesis mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|