Xanthogranulomatous reaction to a ruptured galactocele
| Autor: | Katherine Z. Holcomb, Erin G. Adams, Jean D. Kemp, Leonard C. Sperling |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Histology Erythema Dermatology Lactation Disorders Pathology and Forensic Medicine Lesion Dermis Breast Cyst Biopsy medicine Xanthomatosis Humans skin and connective tissue diseases Galactocele Granuloma medicine.diagnostic_test Rupture Spontaneous CD68 business.industry Macrophages Antibodies Monoclonal Anatomy medicine.disease Squamous metaplasia medicine.anatomical_structure Breast Feeding Female medicine.symptom business Breast feeding Biomarkers |
| Zdroj: | Journal of cutaneous pathology. 37(9) |
| ISSN: | 1600-0560 |
| Popis: | We describe a case of a 34-year-old, healthy, lactating female with a 2-month history of breast pain and an enlarging, tender mass on her right nipple. Her right breast was firm and mildly engorged without mass, warmth or erythema. A tender, yellow nodule was located on the superior aspect of the nipple, obstructing the flow of milk from this portion of the nipple. A biopsy showed epidermal erosion, sheets of cells with massively distended, foamy cytoplasm in the dermis, and a hypertrophied and occluded glandular duct, consistent with reactive squamous metaplasia. Immunostaining for CD68 confirmed the foamy cells were macrophages, and anti-human milk fat globulin-1 (HMFG1) labeled the substance within the macrophages consistent with human breast milk. Therefore, the lesion could be identified as a xanthogranulomatous reaction to a ruptured galactocele. |
| Databáze: | OpenAIRE |
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