Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders
| Autor: | Gerardo Barragán Mejía, David Calderón Guzmán, Monica Punzo Soto, Hugo Juárez Olguín, Ernestina Hernández García, Mayra Santillan Garcia |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Alternative therapy Antiandrogens Central nervous system Pharmacology Biology Bioinformatics Neuroprotection 03 medical and health sciences 0302 clinical medicine Neurochemical medicine Animals Humans Androgen Receptor Antagonists General Neuroscience Androgen Antagonists 030104 developmental biology medicine.anatomical_structure Neuroprotective Agents Steroids Nervous System Diseases 030217 neurology & neurosurgery |
| Zdroj: | CNSneurological disorders drug targets. 16(7) |
| ISSN: | 1996-3181 |
| Popis: | Background & objective Multiple classes of natural products, such as antiandrogens or steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases. This paper aims to review current knowledge on these substances and their possible relationship with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive review of the neurochemical mechanisms of these substances in the central nervous system of humans and animal models is yet to be undertaken in the literature, particularly regarding their importance and increasing use. Conclusion Androgen receptor antagonists act in a different way that may underlie the benefits of natural products, with the expectation that in adults, neurological disorders would respond to natural antiandrogens. We hope that this work would provide valuable insight into the protective and therapeutic roles for natural antiandrogens and steroids in common neurological disorders. |
| Databáze: | OpenAIRE |
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