Nomograms of Fetal Cardiac Dimensions at 18-41 Weeks of Gestation
| Autor: | Merida Rodriguez-Lopez, I. Soveral, Eduard Gratacós, Laura García-Otero, Josep M. Martinez, Olga Gómez, Álvaro Sepúlveda-Martínez, Fatima Crispi, Brenda Valenzuela-Alcaraz, L. Guirado, Marta López, X. Torres |
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| Rok vydání: | 2019 |
| Předmět: |
Heart Defects
Congenital Embryology medicine.medical_specialty Intraclass correlation Medicina intensiva en cardiologia Population Gestational Age Ultrasonography Prenatal 03 medical and health sciences 0302 clinical medicine Fetal Heart Pregnancy Reference Values Internal medicine Prenatal medicine medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Prospective cohort study education education.field_of_study Fetus Cardiac intensive care 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Medicina prenatal Obstetrics and Gynecology Gestational age General Medicine Nomogram Nomograms Echocardiography Pediatrics Perinatology and Child Health Cardiology cardiovascular system Gestation Female business Fetal echocardiography |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Objective: There is a need for standardized reference values for cardiac dimensions in prenatal life. The objective of the present study was to construct nomograms for fetal cardiac dimensions using a well-defined echocardiographic methodology in a low-risk population. Methods: This is a prospective cohort study including 602 low-risk singleton pregnancies undergoing a standardized fetal echocardiography to accurately assess fetal cardiac, ventricular, and atrial dimensions. Parametric regressions were tested to model each measurement against gestational age from 18 to 41 weeks of gestation. Results: Nomograms were constructed for fetal cardiac dimensions (transverse and longitudinal diameters and areas) of the whole heart, atria, and ventricles, as well as myocardial wall thicknesses. All dimensions showed a progressive increase with gestational age. The best model for most parameters was a second-degree linear polynomial. Fetal cardiac, ventricular, and atrial diameters and areas were successfully obtained in 98.6% of the fetuses, while myocardial wall thicknesses could be obtained in 96.5% of the population. The results showed excellent interobserver and intraobserver reproducibility (intraclass correlation coefficient, ICC > 0.811 and ICC > 0.957, respectively). Conclusions: We provide standardized and comprehensively evaluated reference values for fetal cardiac morphometric parameters across gestation in a low-risk population. These no mograms would enable the early identification of different patterns of fetal cardiac remodeling. |
| Databáze: | OpenAIRE |
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