Gut microbiota, metabolites and host immunity
| Autor: | Wendy S. Garrett, Michelle G. Rooks |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
History animal diseases chemical and pharmacologic phenomena Computational biology Biology Gut flora Article Education Microbiology Immunomodulation 03 medical and health sciences Immune system Immunity Animals Homeostasis Humans Microbiome Symbiosis Mutualism (biology) Microbiota Gastrointestinal Microbiome Fatty Acids biochemical phenomena metabolism and nutrition biology.organism_classification Computer Science Applications 030104 developmental biology Mucosal immunology Metagenomics Immune System Receptors Pattern Recognition Host-Pathogen Interactions bacteria Metagenome Disease Susceptibility |
| Zdroj: | Nature reviews. Immunology. 16(6) |
| ISSN: | 1474-1741 |
| Popis: | The microbiota - the collection of microorganisms that live within and on all mammals - provides crucial signals for the development and function of the immune system. Increased availability of technologies that profile microbial communities is facilitating the entry of many immunologists into the evolving field of host-microbiota studies. The microbial communities, their metabolites and components are not only necessary for immune homeostasis, they also influence the susceptibility of the host to many immune-mediated diseases and disorders. In this Review, we discuss technological and computational approaches for investigating the microbiome, as well as recent advances in our understanding of host immunity and microbial mutualism with a focus on specific microbial metabolites, bacterial components and the immune system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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