Dopamine Gene Profiling to Predict Impulse Control and Effects of Dopamine Agonist Ropinirole
| Autor: | Winston D. Byblow, April Ren, Justin Kao, Barry Snow, James P. Coxon, Hayley J. MacDonald, Steven C. Cramer, Lorraine Macdonald, Cathy M. Stinear |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Indoles Cognitive Neuroscience Dopamine Plasma Membrane Transport Proteins Decision Making Pharmacology Stop signal Motor Activity Catechol O-Methyltransferase Dopamine agonist Polymorphism Single Nucleotide Developmental psychology 03 medical and health sciences 0302 clinical medicine Double-Blind Method Dopamine medicine Reaction Time Humans Psychology Genetic Predisposition to Disease Dopamine transporter Aged Catechol-O-methyl transferase biology Dose-Response Relationship Drug Receptors Dopamine D2 Receptors Dopamine D1 Receptors Dopamine D3 Neurosciences Experimental Psychology Middle Aged Impulse control 030104 developmental biology Ropinirole Dopamine Agonists Impulsive Behavior biology.protein Female Cognitive Sciences 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | MacDonald, Hayley J; Stinear, Cathy M; Ren, April; Coxon, James P; Kao, Justin; Macdonald, Lorraine; et al.(2016). Dopamine Gene Profiling to Predict Impulse Control and Effects of Dopamine Agonist Ropinirole.. Journal of cognitive neuroscience, 28(7), 909-919. doi: 10.1162/jocn_a_00946. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9b04v7tk |
| DOI: | 10.1162/jocn_a_00946. |
| Popis: | Dopamine agonists can impair inhibitory control and cause impulse control disorders for those with Parkinson disease (PD), although mechanistically this is not well understood. In this study, we hypothesized that the extent of such drug effects on impulse control is related to specific dopamine gene polymorphisms. This double-blind, placebo-controlled study aimed to examine the effect of single doses of 0.5 and 1.0 mg of the dopamine agonist ropinirole on impulse control in healthy adults of typical age for PD onset. Impulse control was measured by stop signal RT on a response inhibition task and by an index of impulsive decision-making on the Balloon Analogue Risk Task. A dopamine genetic risk score quantified basal dopamine neurotransmission from the influence of five genes: catechol-O-methyltransferase, dopamine transporter, and those encoding receptors D1, D2, and D3. With placebo, impulse control was better for the high versus low genetic risk score groups. Ropinirole modulated impulse control in a manner dependent on genetic risk score. For the lower score group, both doses improved response inhibition (decreased stop signal RT) whereas the lower dose reduced impulsiveness in decision-making. Conversely, the higher score group showed a trend for worsened response inhibition on the lower dose whereas both doses increased impulsiveness in decision-making. The implications of the present findings are that genotyping can be used to predict impulse control and whether it will improve or worsen with the administration of dopamine agonists. |
| Databáze: | OpenAIRE |
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