Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis
| Autor: | Abhirup Das, Spiro Menounos, Philip M. Hansbro, Ashish D. Diwan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
amyotrophic lateral sclerosis (ALS) motor neuron degeneration immunometabolism cigarette smoking Neurosciences. Biological psychiatry. Neuropsychiatry medicine.disease_cause neuroinflammation Pathogenesis 03 medical and health sciences 0302 clinical medicine Medicine oxidative stress Microbiome Epigenetics Amyotrophic lateral sclerosis Neuroinflammation 1109 Neurosciences 1701 Psychology 1702 Cognitive Sciences Neurology & Neurosurgery business.industry medicine.disease Pathophysiology 030104 developmental biology Environmental Risk Factor business Neuroscience 030217 neurology & neurosurgery Oxidative stress RC321-571 |
| Zdroj: | NeuroSci, Vol 2, Iss 8, Pp 120-134 (2021) |
| ISSN: | 2673-4087 |
| Popis: | Cigarette smoke (CS) has been consistently demonstrated to be an environmental risk factor for amyotrophic lateral sclerosis (ALS), although the molecular pathogenic mechanisms involved are yet to be elucidated. Here, we propose different mechanisms by which CS exposure can cause sporadic ALS pathogenesis. Oxidative stress and neuroinflammation are widely implicated in ALS pathogenesis, with blood–spinal cord barrier disruption also recognised to be involved in the disease process. In addition, immunometabolic, epigenetic and microbiome alterations have been implicated in ALS recently. Identification of the underlying pathophysiological mechanisms that underpin CS-associated ALS will drive future research to be conducted into new targets for treatment. |
| Databáze: | OpenAIRE |
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