The Tailgate Study: Differing metabolic effects of a bout of excessive eating and drinking
| Autor: | Nhan T. Lee, Camila Manrique-Acevedo, Qiong Hu, Guido Lastra, Elizabeth J. Parks, Miriam Jacome-Sosa, Ayman H. Gaballah, Bruce D. Bartholow, Jennifer M. Anderson, Nathan C. Winn, Justine M. Mucinski, Majid M. Syed-Abdul, Alhareth Al Juboori |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Health (social science) Alcohol Drinking Poison control Alcohol Hyperphagia Toxicology Biochemistry Young Adult 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine NEFA Internal medicine Dietary Carbohydrates Humans Medicine Overeating Triglycerides business.industry Lipid metabolism General Medicine Carbohydrate Lipid Metabolism 030227 psychiatry Endocrinology Liver Neurology chemistry Lipogenesis Analysis of variance business 030217 neurology & neurosurgery Sports |
| Zdroj: | Alcohol. 90:45-55 |
| ISSN: | 0741-8329 |
| Popis: | Excess energy intake by spectators at a sporting event (i.e., a tailgate) might cause acute negative health effects. However, limited data exist regarding the effects of overeating and alcohol consumption on lipid metabolism and the potential to gain intrahepatic triacylglycerols (IHTG). We tested the hypothesis that overconsumption of food and alcohol would significantly increase both hepatic de novo lipogenesis (DNL) and IHTG.Eighteen males (mean ± SD, age: 31.4 ± 7.3 years, BMI: 32.1 ± 5.9 kg/mSubjects consumed 5087 ± 149 kcal (191 ± 25% excess of total daily energy needs including 171 ± 24 g alcohol), which increased plasma insulin, glucose, TG, and decreased NEFA (ANOVA p ≤ 0.003 for all). Both DNL and TRL-TG increased (p 0.001), while IHTG did not change in the group as a whole (p = 0.229). Individual subject data revealed remarkably differing responses for IHTG (nine increased, five decreased, one did not change). Despite maintaining equal breath alcohol levels, subjects with IHTG elevations exhibited higher DNL, consumed 90% less alcohol (p = 0.048), tended to consume more carbohydrates, and exhibited lower whole-body fat oxidation (not significant) compared to those whose IHTG was reduced.This study demonstrates that acute excess energy intake may have differing effects on an individual's DNL and IHTG, and dietary carbohydrate may influence DNL more than alcohol. |
| Databáze: | OpenAIRE |
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