In vivo diffusion tensor imaging of chronic spinal cord compression : a rat model with special attention to the conus medullaris
| Autor: | Xin Yuan, Peng Zhao, Yanhui Wang, Chao Kong, Hua Guan, Libin Cui, Xueming Chen, Zhenshan Yu |
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| Rok vydání: | 2016 |
| Předmět: |
animal structures
Rat model 030218 nuclear medicine & medical imaging Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine In vivo Spinal cord compression Fractional anisotropy Medicine Effective diffusion coefficient Animals Radiology Nuclear Medicine and imaging Radiological and Ultrasound Technology business.industry General Medicine Anatomy Spinal cord medicine.disease Conus medullaris Disease Models Animal medicine.anatomical_structure Diffusion Tensor Imaging Spinal Cord Chronic Disease Female business Spinal Cord Compression 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Acta radiologica (Stockholm, Sweden : 1987). 57(12) |
| ISSN: | 1600-0455 |
| Popis: | Background Few studies have focused on diffusion tensor imaging (DTI) parameters of the conus medullaris after chronic compression in the cervical spinal cord. Purpose To discuss the correlation of DTI parameters between the chronically compressed cervical spinal cord and the conus medullaris in a rat model at different time points. Material and Methods Fifty female Sprague-Dawley rats were randomized into five groups: control group (group A), sham group (group B), and test groups C, D, and E (1, 2, and 3 weeks after compression, respectively). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of the cervical spinal cord and conus medullaris were compared among different groups. Correlations of ADC and FA values of the cervical spinal cord with those of the conus medullaris were performed in all groups. Results The ADC values at the cervical spinal cord and conus medullaris in all test groups were higher than those of group A and B, while the FA values were lower. The ADC value of the cervical spinal cord was linearly correlated with that of the conus medullaris only in group D. There were no linear correlations of FA values between the cervical spinal cord and the conus medullaris in all test groups. Conclusion After compression of the cervical spinal cord, ADC values of the cervical spinal cord and conus medullaris in test group were significantly increased, while FA values were significantly decreased. The ADC value of the cervical spinal cord was linearly correlated with that of the conus medullaris at 2 weeks after compression. |
| Databáze: | OpenAIRE |
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