Influence of excipients and technological process on anti-inflammatory activity of quercetin and Achyrocline satureioides (Lam.) D.C. extracts by oral route
| Autor: | K. C. B. De Souza, E. E. S. Schapoval, V. L. Bassani |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.drug_class Drug Compounding Pharmaceutical Science Administration Oral Polysorbates Carrageenan Anti-inflammatory law.invention chemistry.chemical_compound law Edema Drug Discovery medicine Animals Achyrocline satureioides Rats Wistar Pharmacology Achyrocline Chromatography biology Dose-Response Relationship Drug Chemistry Plant Extracts Anti-Inflammatory Agents Non-Steroidal biology.organism_classification Rats Complementary and alternative medicine Solvents Molecular Medicine Quercetin medicine.symptom Phytotherapy Luteolin |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 14(2-3) |
| ISSN: | 0944-7113 |
| Popis: | The flavonoids quercetin, 3-O-methylquercetin and luteolin play an important role in the anti-inflammatory activity of Achyrocline satureioides ethanol extracts when administered intraperitoneally. The present work describes the oral anti-inflammatory effect of quercetin and A. satureioides extracts and the role played by the solvent concentration, adjuvant and drying processes of freeze-drying (FD) or spray-drying (SD) on the effect. The best anti-edema effect was observed with 250 mg/kg body wt of the freeze-dried powder (FDP), prepared with 40% (v/v) ethanol (FDP40). In contrast, 250 mg/kg body wt of FDP80, prepared with ethanol 80% (ES80), did not significantly inhibit the carrageenan-induced rat paw edema. However, when ES80 was freeze-dried in the presence of polysorbate 80 (FDP80-P80) or spray-dried in the presence of colloidal silicon dioxide (CSD) and P80 (SDP80), both dried extracts became more active. Quercetin suspension in saline did not inhibit paw edema, but the mixture of quercetin with polysorbate 80 was effective in edema inhibition by the oral route. Aqueous extract (ESAQ), freeze-dried (FDPAQ, FDPAQ-P80) or spray-dried (SDPAQ) did not exhibit the edema-inhibition effect. Taken together, the results point to the following order of efficacy (at 4 h, for example): FDP40 > indomethacin > SDP40 > SDP80 = FDP80-80 > Quercetin-P80. Additionally, the FDP40, SDP40 (prepared from 40% v/v ethanol added of CSD) and SDP80 reduced the total leukocyte and polymorphonuclear cell migration in the pleural cavity. |
| Databáze: | OpenAIRE |
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