Developmental Expression of Platelet-Derived Growth Factor and its Receptor in the Human Placenta
| Autor: | Robert N. Taylor, Lewis T. Williams |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Platelet-derived growth factor Placenta medicine.medical_treatment Receptors Cell Surface Biology chemistry.chemical_compound Paracrine signalling Fetus Endocrinology Pregnancy Internal medicine medicine Humans Receptors Platelet-Derived Growth Factor RNA Messenger Kinase activity Autocrine signalling Receptor Molecular Biology Platelet-Derived Growth Factor Growth factor Nucleic Acid Hybridization General Medicine Cell biology medicine.anatomical_structure Gene Expression Regulation chemistry biology.protein RNA Female Platelet-derived growth factor receptor |
| Zdroj: | Molecular Endocrinology. 2:627-632 |
| ISSN: | 1944-9917 0888-8809 |
| Popis: | To investigate the role of platelet-derived growth factor (PDGF) during human placental development, expression of the genes encoding PDGF, the PDGF-receptor (PDGF-R) and the c-fos protooncogene was measured. Messenger RNAs for these genes were detected throughout pregnancy and peaked coordinately during the second trimester. An identical pattern of PDGF-R protein expression was confirmed by immunoblotting using a specific PDGF-R antiserum, measurement of PDGF-R kinase activity, and [125I]PDGF binding. These findings show that the components of the PDGF pathway are expressed in a concerted fashion throughout human pregnancy and are present at especially high levels during the midtrimester. Our observations suggest that through autocrine and/or paracrine mechanisms, PDGF is likely to play an important role in placental homeostasis. |
| Databáze: | OpenAIRE |
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