Lower Omega-3 index is a marker of increased propensity of hypertensive rat heart to malignant arrhythmias
| Autor: | A Vachulová, Jana Radosinska, Narcis Tribulova, Milan Čertík, Barbara Szeiffova Bacova, Peter Sec |
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| Předmět: |
Male
medicine.medical_specialty Physiology Linoleic acid Blood Pressure Sensitivity and Specificity chemistry.chemical_compound Dietary Fats Unsaturated Heart Rate Risk Factors Internal medicine Rats Inbred SHR Heart rate Fatty Acids Omega-3 medicine Animals Rats Wistar chemistry.chemical_classification alpha-Linolenic acid business.industry food and beverages Reproducibility of Results Arrhythmias Cardiac General Medicine Prognosis Eicosapentaenoic acid Rats Blood pressure Endocrinology chemistry Docosahexaenoic acid Anesthesia Hypertension lipids (amino acids peptides and proteins) Arachidonic acid Female business Biomarkers Polyunsaturated fatty acid |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of omega-3 and omega-6 PUFA as well as to determine omega-3 index, a risk factor for sudden cardiac death, in aged SHR and the effect of omega-3 PUFA intake. Male and female 12-month-old SHR and age-matched Wistar rats fed with omega-3 PUFA (200 mg/kg BW/day/2 month) were compared with untreated rats. Composition of omega-3 PUFA: alpha linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as omega-6 PUFA: linoleic acid and arachidonic acid was analyzed by gas chromatography. Results showed sex- and strain-related differences of basal omega-3 and omega-6 PUFA levels in plasma and RBC as well as in response to omega-3 PUFA intake. Comparing to Wistar rats omega-3 index, expressed as a percentage of EPA+DHA of total fatty acids, was lower in SHR and it increased due to consumption of omega-3 PUFA. Findings support our hypothesis that lower omega-3 index may be also a marker of increased propensity of the hypertensive rat heart to malignant arrhythmias. |
| Databáze: | OpenAIRE |
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