Model of spontaneous obesity in aging male Wistar rats
| Autor: | F. D. Newby, M. DiGirolamo, G. A. Cotsonis, M. H. Kutner |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Aging Physiology Body water Adipose tissue Cell Count Body weight chemistry.chemical_compound Body Water Physiology (medical) Internal medicine Adipocyte medicine Animals Obesity Retroperitoneal Space Epididymis Body Weight Lipid metabolism Rats Inbred Strains medicine.disease Lipid Metabolism Rats Disease Models Animal Endocrinology chemistry Adipose Tissue Lean body mass Body Composition medicine.symptom Energy Metabolism Weight gain |
| Zdroj: | The American journal of physiology. 259(6 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | We analyzed retrospectively data from 148 chow-fed male Wistar rats killed between the age of 6 wk and 2 yr while varying in body weight from 136 to 917 g. The purpose of this study was to clarify the relationship of body weight and body lipid content with the composition and cellularity of the epididymal and retroperitoneal fat depots. A positive linear association was found between body weight and body water or fat-free dry residue, whereas total body lipid exhibited a curvilinear relationship with body weight. The weight of the epididymal pads was linearly related to body weight but not to body lipid. In contrast, retroperitoneal pad weight was exponentially related to body weight and paralleled total body lipid. A strong linear correlation was found between total body lipid and weight (r = 0.959) or depot lipid content (r = 0.967) of the retroperitoneal fat pads. In this rat model of aging and spontaneous obesity, significant regional differences exist in adipose depot composition and cellularity. A practical outcome of this study is a simple and accurate prediction of body lipid content from the gravimetric determination of the retroperitoneal fat depots. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|