| Popis: |
CXCR4 is a chemokine receptor specific for stromal-derived factor-1 (SDF-1 α, CXCL12) that regulate a variety of cell functions and involved in the spread and progression of a variety of different tumors. Accumulating evidence suggests that CXCR4 and SDF-1α expression is useful for evaluating the risk of gastric cancer progression, however, their influence on the occurrence and development of gastric cancer (GC) requires further investigation. In the present study there was provided analysis of the association of CXCR4 expression both in GC and bone marrow (BM) with clinical characteristics using immunohistochemistry, immunocytochemistry, NMR-spectroscopy and zymography as well as overall survival (OS) of 65 patients with GC. It was shown that CXCR4 was expressed in 78.5% of GC specimens and correlated with tumor hypoxia (p0 category. Overall survival (OS) of patients with CXCR4-positive tumors was poorer than that of patients with CXCR4-negative tumors (p=0.037). CXCR4 expression in BM was not associated with OS. Risk of unfavourable outcome is increased in patients with M0 category and with both CXCR4-positive BM and DTCs (𝑃 = 0.03). |
