Modulation of the human preadipocyte mitochondrial activity by beta-carotene
| Autor: | U. Czech, Anna Gruca, Barbara Zapała, Joanna Góralska, Anna Polus, Agnieszka Sliwa, Aldona Dembińska-Kieć |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
preadipocytes
Antioxidant Bioenergetics medicine.medical_treatment oxidative phosphorylation Retinoic acid Oxidative phosphorylation Mitochondrion Oxidative Phosphorylation General Biochemistry Genetics and Molecular Biology Cell Line chemistry.chemical_compound Adenosine Triphosphate Adipocytes medicine Humans Membrane Potential Mitochondrial chemistry.chemical_classification Membrane potential Reactive oxygen species beta Carotene Mitochondria mitochondria beta-carotene chemistry Biochemistry Cell culture |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1734-154X 0001-527X |
| Popis: | Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria. |
| Databáze: | OpenAIRE |
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