| Autor: |
Kevan T. Knizner, Jacob P. Guymon, Kenneth P. Garrard, Guy Bouvrée, Jeffrey Manni, Jan-Peter Hauschild, Kerstin Strupat, Kyle L. Fort, Lee Earley, Eloy R. Wouters, Fan Pu, Andrew J. Radosevich, Nathaniel L. Elsen, Jon D. Williams, Mark R. Pankow, David C. Muddiman |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of the American Society for Mass Spectrometry. 33(11) |
| ISSN: |
1879-1123 |
| Popis: |
Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is a hybrid, ambient ionization source that combines the advantages of electrospray ionization and matrix-assisted laser desorption/ionization, making it a versatile tool for both high-throughput screening (HTS) and mass spectrometry imaging (MSI) studies. To expand the capabilities of the IR-MALDESI source, an entirely new architecture was designed to overcome the key limitations of the previous source. This next-generation (NextGen) IR-MALDESI source features a vertically mounted IR-laser, a planar translation stage with computerized sample height control, an aluminum enclosure, and a novel mass spectrometer interface plate. The NextGen IR-MALDESI source has improved user-friendliness, improved overall versatility, and can be coupled to numerous Orbitrap mass spectrometers to accommodate more research laboratories. In this work, we highlight the benefits of the NextGen IR-MALDESI source as an improved platform for MSI and direct analysis. We also optimize the NextGen MALDESI source component geometries to increase target ion abundances over a wide |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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