Dendritic organosilica nanospheres with large mesopores as multi-guests vehicle for photoacoustic/ultrasound imaging-guided photodynamic therapy
| Autor: | Limin Wu, Yuting Huang, Chun Shan, Min Chen, Kaiwen Shen, Hongchong Guo, Yinsong Si |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Indocyanine Green
medicine.medical_treatment Nanoparticle Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials chemistry.chemical_compound Colloid and Surface Chemistry Cell Line Tumor medicine Ultrasonography Photosensitizing Agents Tumor hypoxia Singlet oxygen Hydrogen Peroxide 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Mesoporous organosilica Photochemotherapy chemistry Cancer cell Nanoparticles 0210 nano-technology Mesoporous material Indocyanine green Nanospheres Biomedical engineering |
| Zdroj: | Journal of Colloid and Interface Science. 583:166-177 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2020.09.028 |
| Popis: | Photodynamic therapy (PDT) is a minimally invasive treatment strategy that uses photosensitizers and light in combination with oxygen to generate cytotoxic singlet oxygen (1O2) to kill cancer cells by necrosis or apoptosis. However, the treatment effects are still not satisfactory because of the tumor hypoxia and the PDT-induced oxygen consumption. Here, we have successfully synthesized dendritic mesoporous organosilica nanoparticles (MONs) with large center-radial pore structure that can be used to simultaneously encapsulate indocyanine green (ICG |
| Databáze: | OpenAIRE |
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