The plasticity of the defecation reflex pathway in the enteric nervous system of guinea pigs
| Autor: | Hiroki Kuniyasu, Miyako Takaki, Hiroko Matsuyoshi, Renta Katsui, Yoshiyuki Nakajima, Hisao Fujii |
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| Rok vydání: | 2009 |
| Předmět: |
Nervous system
Colon Physiology Morpholines Guinea Pigs Anal Canal Rectum Internal anal sphincter Colon surgery Animals Medicine Peripheral Nerves Defecation Myenteric plexus Neuronal Plasticity Rectal Neoplasms business.industry Brain-Derived Neurotrophic Factor Stem Cells General Medicine Anatomy Serotonin Receptor Agonists medicine.anatomical_structure Benzamides Reflex Enteric nervous system business |
| Zdroj: | Journal of Smooth Muscle Research. 45:1-13 |
| ISSN: | 0916-8737 |
| DOI: | 10.1540/jsmr.45.1 |
| Popis: | The enteric nervous system, the "second" brain, is an independent nervous system that structurally resembles the "first" brain. Appropriate rectal distension elicits rectal (R-R) reflex contractions and simultaneous internal anal sphincter (R-IAS) reflex relaxations that together comprise the defecation reflex. The enteric nervous system, pelvic nerves and lumbar colonic nerves control both reflexes. Using the plasticity of enteric nervous pathways, a new therapy for repairing enteric neural dysfunction could be developed. In vivo experiments were performed on guinea pigs anesthetized with ethyl carbamate. We performed either a lower anterior resection as used for rectal cancer, without damaging the extrinsic nerves or a resection of a 2-cm segment of distal colon, 30 mm orally from the anal verge, with subsequent end-to-end one layer anastomosis of the exposed ends. The recovery of the defecation reflex was found to be the same in both the rectal transection and distal colonic resection procedures. Eight weeks after sectioning the intrinsic reflex nerve pathways in the rectum, the defecation reflex recovered to control levels, accompanied by a regeneration of the reflex pathways. The 5-HT(4) receptor agonist, mosapride (0.5 and 1.0 mg/kg), significantly (P |
| Databáze: | OpenAIRE |
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