CT-guided thin needles percutaneous cryoablation (PCA) in patients with primary and secondary lung tumors: A preliminary experience
| Autor: | Claudio Pusceddu, Barbara Sotgia, Luca Melis, Rosa Maria Fele |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Radiofrequency ablation medicine.medical_treatment Pilot Projects Cryosurgery Sensitivity and Specificity Asymptomatic law.invention law medicine Humans Radiology Nuclear Medicine and imaging Aged Aged 80 and over Lung medicine.diagnostic_test business.industry Reproducibility of Results Cryoablation Interventional radiology Common Terminology Criteria for Adverse Events General Medicine Middle Aged medicine.disease Treatment Outcome medicine.anatomical_structure Surgery Computer-Assisted Pneumothorax Needles Female Radiology Pulmonary hemorrhage medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | European Journal of Radiology. 82:e246-e253 |
| ISSN: | 0720-048X |
| Popis: | To report the data of our initial experience with CT-guided thin cryoprobes for percutaneous cryoablation (PCA) in patients with primary and secondary pulmonary tumors.CT-guided thin needles PCA was performed on 34 lung masses (11 NSCLC=32%; 23 secondary lung malignancies=68%) in 32 consecutive patients (24 men and 8 women; mean age 67 ± 10 years) not suitable for surgical resection. Lung masses were treated using two types of cryoprobes: IceRod and IceSeed able to obtain different size of iceball. The number of probes used ranged from 1 to 5 depending on the size of the tumor. After insertion of the cryoprobes into the lesion, the PCA were performed with two 2 (91%) or 3 (9%) cycles each of 12 min of freezing followed by a 4 min active thawing phase and a 4 min passive thawing phase for each one for all treatments.All cryoablation sessions were successfully completed. All primary and metastatic lung tumors were ablated. No procedure-related deaths occurred. Morbidity consisted of 21% (7 of 34) pneumothorax and 3% (1 of 34) cases asymptomatic small pulmonary hemorrhage, respectively, all of CTCAE grade 1 (Common Terminology Criteria for Adverse Events). Low density of entire lesion, central necrosis and solid mass appearance were identify in 21 (62%), 7 (21%) and 6 (17%) of cryoablated tumors, respectively. No lymphadenopathy developed in the region of treated lesions. Technical success (complete lack of enhancement) was achieved in 82%, 97% and 91% of treated lesions at 1-, 3- and 6-months CT follow-up scan, respectively (p.000). Comparing the tumor longest diameter between the baseline and at 6 month CT images, technical success was revealed in 92% cases (p.000).Our preliminary experience suggests that PCA is a feasible treatment option. Well-designed clinical trials with a larger patient population are necessary to further investigate the long-term results and prognostic factors. |
| Databáze: | OpenAIRE |
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