Drug-facilitated sexual assault (DFSA) involving 4-methylethcathinone (4-MEC), 3,4-Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis
| Autor: | Isabelle Etting, Jean-Claude Alvarez, Islam Amine Larabi, Pauline Penot, Nicolas Fabresse, Marie Martin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Pharmaceutical Science Methylenedioxypyrovalerone Poison control Pharmacology 01 natural sciences Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Drug facilitated sexual assault Environmental Chemistry 030216 legal & forensic medicine Spectroscopy business.industry 010401 analytical chemistry Hair analysis 0104 chemical sciences Designer drug Stimulant chemistry Doxylamine 4-Methylethcathinone business medicine.drug |
| Zdroj: | Drug Testing and Analysis. 10:1280-1284 |
| ISSN: | 1942-7603 |
| DOI: | 10.1002/dta.2377 |
| Popis: | Recently, the emergence of new psychoactive substances (NPS) has led to their wide use among clubbers and men who have sex with men (MSM) for their stimulant effects. However, their use in drug-facilitated sexual assault (DFSA) has rarely been described. Herein we report a case of a 44-year-old man who was assaulted after a party. Due to late reporting of the offense, only hair (black) was sampled 15 days later and a segmental analysis was achieved to look for most DFSA agents and NPS. Twenty mg of each segment (A: 0-1 cm, B: 1-3 cm, and C: 3-5 cm) were incubated in phosphate buffer pH 5.0. After alkaline liquid extraction and chromatographic separation on 1.9 μm Hypersil GOLD PFP column, compounds were detected by a TSQ Vantage mass spectrometer with electrospray ionization in positive mode with multiple reaction monitoring (MRM) acquisition. 4-methylethcathinone (4-MEC), methylenedioxypyrovalerone (MDPV) and doxylamine were found in proximal segment at very low concentrations (3, 5, and 9 pg/mg, respectively) which is in agreement with a single exposure in the previous month corresponding to the alleged facts. These substances were not detected in segments B and C showing a lack of repetitive exposure before the alleged event. Thus, the results do not contradict the patient's claim of being assaulted. Doxylamine has already been encountered in such cases but no publications referring to 4-MEC or MDPV use have ever been documented. Our case reports the unusual administration of cathinones to achieve a sexual assault and stresses the interest of looking for designer drugs when dealing with DFSA cases. |
| Databáze: | OpenAIRE |
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