Apolipoproteins E and C-III in apo B- and non-apo B-containing lipoproteins in middle-aged women from the Stanislas cohort: effect of oral contraceptive use and common apolipoprotein E polymorphism
| Autor: | B. Beaud, Françoise Schiele, Bernard Herbeth, Sophie Visvikis, Gérard Siest, M Vincent-Viry, M Starck |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein B Lipoproteins Apolipoprotein E4 Hyperlipidemias Biology Body Mass Index Contraceptives Oral Hormonal Apolipoproteins E Cohort Studies Risk Factors Oral administration Internal medicine medicine Humans Protein Isoforms Allele Apolipoproteins C Triglycerides Apolipoproteins B Apolipoprotein C-III Polymorphism Genetic Middle Aged Cholesterol Endocrinology Biochemistry Cardiovascular Diseases biology.protein Female lipids (amino acids peptides and proteins) France Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Atherosclerosis. 155:509-516 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/s0021-9150(00)00600-6 |
| Popis: | Oral contraceptive (OC) use and common apo E polymorphism are well known to modify serum lipid and lipoprotein concentrations. The combined effect of OC use and apo E genotype on the concentration of apo E or apo C-III in apo B- (apo E-LpB or apo C-III-LpB) or in non-apo B-containing lipoparticles (apo E-Lp-non-B or apo C-III-Lp-non-B) are unknown. Our study comprised 613 women, aged 30-45 years, genotyped for common apo E polymorphism and who differed in their combined low-dose OC consumption. The concentrations of apo C-III, apo C-III-LpB and apo C-III-Lp-non-B were significantly higher in OC users than in non-users by 13, 23 and 8% respectively, without significant interaction with the apo E genotype. The concentrations of apo E and apo E-Lp-non-B were significantly lower (differences being -14% and -31% respectively) in OC users than in controls whereas the apo E-LpB concentration was significantly higher (+19%), resulting in a redistribution of apo E from Lp-non-B towards LpB. Total apo E and apo E-Lp-non-B concentrations were higher in subjects carrying the epsilon2 allele and lower in those with the epsilon4 allele when compared to epsilon3/epsilon3 subjects (P < 0.001). The opposite held for the apo E- LpB concentration (P < 0.05). The main finding is the significant interaction between apo E genotype and OC use (P < 0.01) on apo E-Lp-non-B concentration, the epsilon4 carriers showing the smallest differences between OC users and non-users in comparison with the epsilon2 or epsilon3/epsilon3 carriers. These results suggest that the common apo E polymorphism can modulate the OC use effect. |
| Databáze: | OpenAIRE |
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