A case-control study of risk factors for death from 2009 pandemic influenza A(H1N1): is American Indian racial status an independent risk factor?

Autor: Hennessy, T. W., Bruden, D., Castrodale, L., Komatsu, K., Erhart, L. M., Thompson, David, Bradley, K., O'Leary, D. R., McLaughlin, J., Landen, M., Bentley, Steve, Keck, James, Kitka, Sassa, Thompson, Gail, Fearey, Donna, Redwood, Diana, Craig, Jessica, Provost, Ellen, Robinson, Keisha, Noble, Rhonda, Burnsed, Laurence, Dougherty, Kendra, Lee, Anthony, McDonald-Hamm, Christie, Smithee, Laura, Williams, Jean, McClinton, Reginald, Tran, Annie, Redd, John, Cheek, James, Bryan, Ralph, Jhung, Michael, Tarkhashvili, Nato, Danila, Richard, Leman, Richard, Wells, Eden, Lofy, Kathy, Miller, Tracy
Rok vydání: 2015
Předmět:
Zdroj: Epidemiology and Infection. 144:315-324
ISSN: 1469-4409
0950-2688
DOI: 10.1017/s0950268815001211
Popis: SUMMARYHistorically, American Indian/Alaska Native (AI/AN) populations have suffered excess morbidity and mortality from influenza. We investigated the risk factors for death from 2009 pandemic influenza A(H1N1) in persons residing in five states with substantial AI/AN populations. We conducted a case-control investigation using pandemic influenza fatalities from 2009 in Alaska, Arizona, New Mexico, Oklahoma and Wyoming. Controls were outpatients with influenza. We reviewed medical records and interviewed case proxies and controls. We used multiple imputation to predict missing data and multivariable conditional logistic regression to determine risk factors. We included 145 fatal cases and 236 controls; 22% of cases were AI/AN. Risk factors (P < 0·05) included: older age [adjusted matched odds ratio (mOR) 3·2, for >45 years vs.
Databáze: OpenAIRE