Visible-Light-Promoted Hydroxydifluoroalkylation of Alkenes Enabled by Electron Donor–Acceptor Complex

Autor:	Kai Chen, Jun-An Xiao, Jian-Ping Guan, Zhen-Zhen Xie, Hua Yang, Yu Zheng, Xiaoqing Chen, Hao-Yue Xiang, Chu-Ping Yuan, Kai Tang
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Chemistry Organic Chemistry Substrate (chemistry) Regioselectivity Electron donor Photochemistry Biochemistry Acceptor chemistry.chemical_compound Physical and Theoretical Chemistry Tertiary alcohols Alkyl Visible spectrum
Zdroj:	Organic Letters. 23:9474-9479
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03655
Popis:	A catalyst-free strategy for regioselective hydroxydifluoroalkylation of alkenes with alkyl bromides was developed, affording a series of difluoroalkylated tertiary alcohols in moderate to good yields. This photocatalyst-free protocol shows broad substrate scope under mild conditions. Moreover, mechanistic studies revealed that a newly identified electron donor-acceptor complex is crucial to this transformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd8bbb57cb55154f38d93aa25f7b68 https://doi.org/10.1021/acs.orglett.1c03655 Zobrazit plný text záznamu