Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pressure
| Autor: | T. S. McDowell, P L Xie, Mark W. Chapleau, Francois M. Abboud, G. Hajduczok |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Baroreceptor Hypertension Renal Blood Pressure Pressoreceptors chemistry.chemical_compound Internal medicine Internal Medicine medicine Animals Chronic hypertension Lagomorpha Nerve activity biology business.industry Chloralose Carotid sinus biology.organism_classification Blood pressure medicine.anatomical_structure Carotid Sinus chemistry Anesthesia Cardiology Female Rabbits business |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 17(1) |
| ISSN: | 0194-911X |
| Popis: | The purpose of this study was to examine the ability of baroreceptors of renal hypertensive rabbits to reset rapidly during acute changes in arterial pressure. The carotid sinus (CS) was vascularly isolated and baroreceptor activity was recorded during slow ramp increases in CS pressure in hypertensive (one-kidney, one wrap; 127 +/- 3 mm Hg) and normotensive (one-kidney, no wrap; 85 +/- 3 mm Hg) rabbits anesthetized with chloralose. Control measurements were made after holding pressure for 10-15 minutes at the level of arterial pressure recorded before each experiment. Baroreceptor threshold pressure (Pth) was higher in hypertensives (78 +/- 4 mm Hg) compared with normotensives (55 +/- 3 mm Hg, p less than 0.05), and nerve activity was less in hypertensives over a wide range of pressure. CS distensibility (sonomicrometers) was not significantly different in the two groups. After increasing holding pressure from control by 30 and 60 mm Hg for 10-15 minutes, the extent of baroreceptor resetting (delta Pth/delta holding pressure x 100%) in normotensives was 39 +/- 6% and 33 +/- 2%, respectively, but only 14 +/- 5% and 9 +/- 3% in hypertensives (p less than 0.05). After decreasing holding pressure by 30 and 60 mm Hg, resetting was similar in normotensives (32 +/- 6% and 28 +/- 3%) and hypertensives (34 +/- 3% and 30 +/- 4%). In hypertensive rabbits, acute (10-15 minutes) exposure of baroreceptors to normotension (71 +/- 4 mm Hg) decreased Pth to 62 +/- 4 mm Hg and increased nerve activity to levels not significantly different from those of normotensive animals without altering CS distensibility.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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