Skin Collagen Biosynthesis In Patients With Rheumatoid Arthritis Treated With D-Penicillamine
| Autor: | Alastair G. Mowat, Martin J. O. Francis, D. Schorn, Mary Loudon |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Specimen Handling Arthritis Rheumatoid Tissue culture Rheumatology Internal medicine medicine Protein biosynthesis Humans Immunology and Allergy In patient Aged Skin business.industry Penicillamine General Medicine Middle Aged medicine.disease Collagen biosynthesis Skinfold Thickness Continuous treatment Endocrinology Protein Biosynthesis Rheumatoid arthritis Female Collagen business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 8:124-128 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.3109/03009747909105350 |
| Popis: | Collagen biosynthesis was measured in skin biopsies taken from 13 patients with rheumatoid arthritis before and after at least 6 months' continuous treatment with D-penicillamine, 1.0 g/day. There was a significant 36% reduction in mean collagen biosynthesis (p less than 0.0125) as assayed by 14C-hydroxyproline formation from 14C-proline during 24 h of tissue culture. The changes in 14C-hydroxyproline formation were correlated with the total doses of D-penicillamine taken (r = 0.71, p less than 0.01) and the falls in ESR (r = 0.72, p less than 0.01). No significant change in general protein syntehsis was observed. 500 microgram/mlD-penicillamine added to skil cultures in vitro inhibited both collagen and general protein synthesis (p less than 0.01). It is suggested that the clinical improvement induced by D-penicillamine could reflect an inhibition of collagen proliferation in the synovium. |
| Databáze: | OpenAIRE |
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