Weight changes and the risk of knee osteoarthritis requiring arthroplasty
| Autor: | O Suomalainen, Pirjo Manninen, Markku Heliövaara, Hilkka Riihimäki |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Risk Aging medicine.medical_specialty medicine.medical_treatment Immunology Population macromolecular substances Overweight Weight Gain General Biochemistry Genetics and Molecular Biology Rheumatology Internal medicine Odds Ratio medicine Humans Immunology and Allergy Risk factor skin and connective tissue diseases Arthroplasty Replacement Knee education Aged education.field_of_study business.industry Patient Selection Age Factors Odds ratio Middle Aged Osteoarthritis Knee Arthroplasty Confidence interval Extended Report Logistic Models Case-Control Studies Relative risk Physical therapy Female sense organs medicine.symptom business Weight gain |
| Zdroj: | Annals of the Rheumatic Diseases. 63:1434-1437 |
| ISSN: | 0003-4967 |
| Popis: | Objective: To examine the effect of weight changes between 20 and 50 years of age on the risk of severe knee osteoarthritis (OA) requiring arthroplasty. Subjects and methods: Cases were 55–75 year old men and women (n = 220) having had knee arthroplasty for primary osteoarthritis at the Kuopio University Hospital in 1992–93. Controls (n = 415) were randomly selected from the population of Kuopio Province. Weight at the age of 20, 30, 40, and 50 years was collected retrospectively with a postal questionnaire. Results: After adjustment for age, sex, history of physical workload, recreational physical activity, and previous knee injury, weight gain resulting to a shift from normal body mass index (BMI ⩽25 kg/m 2 ) to overweight (BMI >25 kg/m 2 ) was associated with a higher relative risk of knee OA requiring arthroplasty than persistent overweight from 20−50 years of age, compared with those with normal relative weight during the corresponding age period. The odds ratios (OR) were 3.07 (95% confidence interval 1.87 to 5.05) for those with normal weight at the age of 20 years and overweight at two or three of the ages 30, 40 or 50 years, 3.15 (1.85 to 5.36) for those with overweight from the age of 30 years, and 2.37 (1.21 to 4.62) for those with overweight from the age of 20 years, respectively. Conclusion: In adult life, a shift from normal to overweight may carry a higher risk for knee OA requiring arthroplasty than does constant overweight. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|