A Fatal Complication of Liver Transplant: Posttransplant Lymphoproliferative Disease

Autor: Hayriye Hizarcioglu-Gulsen, Ersin Gumus, Hulya Demir, Inci N. Saltik-Temizel, Ali Varan, Hilmi Anil Dincer, Ahmet Bulent Dogrul, Hasan Ozen
Rok vydání: 2022
Předmět:
Zdroj: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 20(Suppl 3)
ISSN: 2146-8427
Popis: Immunosuppressive therapy is a double-edged sword and causes a risk for some complications, such as opportunistic infections and posttransplant lymphoproliferative disease. The most likely risk factors for posttransplant lymphoproliferative disease are Epstein-Barr virus serology mismatch, prolonged and high viral load for Epstein-Barr virus, higher doses of immunosuppressive therapy, and cytomegalovirus infection. Transplant recipients who are seropositive for Epstein-Barr virus show a lower risk for posttransplant lymphoproliferative disease than seronegative recipients. Here, we present a 3.5-year-old boy who was seropositive for Epstein-Barr virus and developed posttransplant lymphoproliferative disease 18 months after liver transplant with a previous history of cytomegalovirus- related pneumatosis intestinalis.
Databáze: OpenAIRE