Dietary factors and microRNA-binding site polymorphisms in the IL13 gene: risk and prognosis analysis of colorectal cancer
| Autor: | Yashuang Zhao, Zhiping Long, Junde Zhou, Lin Zhu, Jing Li, Jingshen Tian, Fan Wang, Chen Gong, Hongyuan Yu, Yanming Yu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Veterinary medicine medicine.medical_specialty Genotype Colorectal cancer colorectal cancer Single-nucleotide polymorphism Gut flora Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Odds Ratio medicine Humans Allele Genotyping Alleles Aged miRNA-binding site Binding Sites Interleukin-13 biology business.industry Odds ratio Middle Aged Prognosis medicine.disease biology.organism_classification Diet Gastrointestinal Microbiome MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Female IL13 Disease Susceptibility dietary factors polymorphisms Colorectal Neoplasms business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.17649 |
| Popis: | // Yanming Yu 1, * , Junde Zhou 2, * , Chen Gong 1 , Zhiping Long 1 , Jingshen Tian 1 , Lin Zhu 1 , Jing Li 1 , Hongyuan Yu 1 , Fan Wang 1 and Yashuang Zhao 1 1 Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China 2 Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, P. R. China * These authors have contributed equally to this work Correspondence to: Fan Wang, email: yifan.701@163.com Yashuang Zhao, email: zhao_yashuang@263.net Keywords: dietary factors, miRNA-binding site, polymorphisms, IL13, colorectal cancer Received: December 20, 2016 Accepted: April 21, 2017 Published: May 07, 2017 ABSTRACT Long-term dietary intake influences the structure and activity of microorganisms residing in the human gut. The immune response and gut microbiota have a mutual influence on the risk of colorectal cancer (CRC). This study examines the association of gut microbiota–related dietary factors and polymorphisms in the microRNA-binding site of the interleukin 13 gene ( IL13 ) with the risk and prognosis of CRC. Three polymorphisms (rs847, rs848, and rs1295685) were selected for genotyping in a case–control study (513 cases, 572 controls), and 386 CRC patients were followed up. Two dietary factors closely related with gut microbiota (allium vegetables, overnight meal) were significantly associated with CRC development. Although the three SNPs showed no statistically significant associations with the risk and prognosis of CRC, a significant antagonistic interaction was found between rs848 (G–T) and allium vegetable intake (ORi (odds ratio of interaction), 0.92; 95% CI (confidence interval): 0.86, 0.99; P = 0.03); moreover, significant combined and synergistic interactions were observed for all three SNPs and overnight meal intake. This is the first report of significant combined and interactive effects between dietary factors and polymorphisms in the microRNA binding site of IL13 in CRC and may provide direct guidance on intake of allium vegetable and overnight meals for individuals with specific genetic variants of IL13 to modify their susceptibility to CRC. |
| Databáze: | OpenAIRE |
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