| Autor: |
Aly, D., Mohammed, F., Sayed, K., Gawdat, H., Mashaly, H., Abdel Hay, R., Elias, T., Agaiby, M. |
| Rok vydání: |
2017 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.5446468.v1 |
| Popis: |
Background: High interleukin (IL)-17 contributes to vitiligo pathogenesis. Vitamin D has been assessed in vitiligo, with no reports targeting its relation to IL-17. Objective: To evaluate a possible regulatory effect of vitamin D on IL-17 and their relation to disease activity in vitiligo. Methods: This study included 30 vitiligo patients and 40 controls evaluated for IL-17 and vitamin D serum levels by ELISA technique. Results: IL-17 was significantly higher (p = 0.001) whereas vitamin D was found to be lower among the patients (p < 0.001). Multivariable regression was performed to evaluate the relationship between IL-17 and vitamin D levels with the demographic data on the patients, revealing a nonsignificant relationship (p > 0.05). A significant positive correlation was noted between vitamin D levels and disease duration. Conclusion: Vitamin D represents a potential player in the pathogenesis of vitiligo. Its possible regulatory relation to IL-17, together with its weight as a screening tool in vitiligo, needs further evaluation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
