Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions
| Autor: | Yi Shiu Lin, Mei Hsiu Lin, Song Chow Lin, Chun Ching Lin, Chi Feng Liu |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Pathology medicine.medical_specialty Antioxidant Necrosis medicine.medical_treatment Administration Oral Pharmacology medicine.disease_cause Antioxidants Propolis Lipid peroxidation chemistry.chemical_compound Oral administration medicine Gastric mucosa Animals Stomach Ulcer Rats Wistar Dose-Response Relationship Drug Ethanol business.industry Plant Extracts Stomach General Medicine Anti-Ulcer Agents Cytoprotection Rats medicine.anatomical_structure Complementary and alternative medicine chemistry Gastric Mucosa Lipid Peroxidation medicine.symptom business Oxidative stress Phytotherapy |
| Zdroj: | The American journal of Chinese medicine. 30(2-3) |
| ISSN: | 0192-415X |
| Popis: | Acute p.o. administration of absolute ethanol (1.0 ml/kg) to fasted rats produced extensive necrosis of gastric mucosa. Pretreatment with p.o. administration of propolis ethanol extract (PEE) could effectively and dose-dependently prevent such necrosis. This protective effect is called "cytoprotection." The maximal cytoprotective effect against absolute ethanol (AE)-induced gastric mucosal lesion was observed 1 hour after PEE administration. A gross examination of the gastric mucosa showed a marked improvement in groups receiving PEE. In order to further investigate the gastric protective mechanism of PEE, lipid peroxidation (LPO) levels in vivo and in vitro were estimated. PEE exhibited dose-dependent superoxide scavenging activity and antioxidant effects on AE-induced LPO in rat gastric mucosal homogenates. It was concluded that the gastric protective mechanism of PEE was due, at least in part, to its ability to inhibit LPO, and hence indirectly protect the gastric mucosa from oxidative stress. |
| Databáze: | OpenAIRE |
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