Adipocytokines in Graves’ orbitopathy and the effect of high-dose corticosteroids
| Autor: | Marta Karhanová, Michal Krupka, David Karasek, Lubica Cibickova, Veronika Kucerova, Zdenek Frysak, Jan Schovanek, Sunaina Reddy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty Histology endocrine system diseases genetic structures Physiology Adipokine Adipose tissue Inflammation Autoimmune thyroid disease Gastroenterology Diseases of the endocrine glands. Clinical endocrinology Adrenal Cortex Hormones Internal medicine medicine Humans QP1-981 In patient adipokines QH573-671 business.industry Cell Biology RC648-665 eye diseases methylprednisolone Graves Ophthalmopathy graves’ orbitopathy Methylprednisolone Cytokines sense organs medicine.symptom business Cytology Research Article Research Paper medicine.drug |
| Zdroj: | Adipocyte, Vol 10, Iss 1, Pp 456-462 (2021) Adipocyte article-version (VoR) Version of Record |
| ISSN: | 2162-3945 |
| Popis: | Graves’ orbitopathy (GO) is a serious, progressive eye condition seen in patients with autoimmune thyroid disease. GO is characterized by inflammation and swelling of soft orbital tissues. Adipose tissue produces cytokine mediators called adipokines. The present study focuses on the relationship between serum levels of selected adipokines in patients with GO, comparing them with the control group, and uniquely describes the effect of high-dose systemic corticosteroids (HDSC) on their levels. For the purposes of this study, we collected blood samples before and after the treatment with HDSC from 60 GO patients and 34 control subjects and measured serum levels of adiponectin, AIF-1, A-FABP and FGF-21. Levels of adiponectin significantly differed among the three study groups (ANOVA p = 0.03). AIF-1 levels were also significantly different among the study groups (ANOVA p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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