Parietal Involvement in the Semantic Variant of Primary Progressive Aphasia with Alzheimer’s Disease Cerebrospinal Fluid Profile
| Autor: | Géraldine Bera, Marie-Odile Habert, Sophie Ferrieux, Hugo Bertin, Bruno Dubois, Thibaut Michelin, Foudil Lamari, Aurélie Kas, Marc Teichmann, Raffaella Migliaccio, Marie Nogues |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Perfusion scanning Disease Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Alzheimer Disease Parietal Lobe Humans Medicine Aged Tomography Emission-Computed Single-Photon business.industry General Neuroscience Parietal lobe General Medicine Middle Aged medicine.disease Semantics Psychiatry and Mental health Clinical Psychology Aphasia Primary Progressive 030104 developmental biology Posterior cingulate Biomarker (medicine) Female Geriatrics and Gerontology business Perfusion Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 66:271-280 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-180087 |
| Popis: | Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer's disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant. |
| Databáze: | OpenAIRE |
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