Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: a pilot study
| Autor: | Tommaso Tartaglione, Vincenzo Arena, Sabrina Chiloiro, Alfredo Pontecorvi, Liverana Lauretti, Laura De Marinis, Pier Paolo Mattogno, Quintino Giorgio D'Alessandris, Flavia Angelini, Antonio Bianchi, Antonella Giampietro, Egidio Stigliano |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pituitary gland Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Context (language use) Pilot Projects Clinical Management of Endocrine Diseases Autoimmunity Hypopituitarism Gastroenterology Autoimmune Diseases Pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Immune system Pituitary adenoma Internal medicine medicine Humans Autoimmune Hypophysitis health care economics and organizations Autoantibodies Immunity Cellular biology business.industry medicine.disease medicine.anatomical_structure Pituitary Gland Autoimmune hypophysitis biology.protein Cell mediated immune response Antibody business Anti-pituitary antibody 030217 neurology & neurosurgery |
| Zdroj: | Endocrine |
| ISSN: | 1559-0100 |
| Popis: | Introduction Primary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs. Material and methods Serum anti-pituitary and anti-hypothalamus antibodies (respectively APAs and AHAs) were investigated though an indirect immunofluorescence on monkey hypophysis and hypothalamus slides, serum cytokines though an array membrane and cell-mediated immunity though the white blood cells count. Results Nineteen PAH cases entered the study. APA or AHA were identified in all cases. APA were detected in 13 patients (68.4%) and AHA in 13 patients (68.4%). Ten patients (52.6%) were simultaneously positive for both APA and AHA. The prevalence of APAs and AHAs was higher as compared to those observed in 50 health controls (respectively 14% p p = 0.004) and in 100 not-secreting pituitary adenoma (NFPAs) (respectively 22% p = 0.002 and 8% p p p = 0.002). No differences were identified between PAHs and controls at qualitative and quantitative analysis of serum cytokines and white blood cells count. Conclusions This study suggest that APA and AHA may be detected in an high percentage of PAH cases and that their simultaneous identification may be useful for the differential diagnosis between PAH and NFPAs, in an appropriate clinical context. |
| Databáze: | OpenAIRE |
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